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Todays approval in the frontline consolidation phase, regardless of MRD status, allows us to reach more patients than ever with this transformative, first-in-class Bispecific T-cell Engager (BiTE) therapy, Jay Bradner, executive vice president of research and development and chief scientific officer at Amgen, said in a press release

Its reduced IGFBP binding means that a greater proportion of the peptide remains free to interact with the IGF-1 receptor (IGF-1R), making it a more potent and predictable tool for in vitro research

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both are normal variations in how individuals adapt to these medications